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Hughes Syndrome Foundation
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There are many ways in which blood clots can affect the body. Some are obvious and dramatic – for example the leg vein clot “deep vein thrombosis” (DVT) that has sometimes been linked with crowded conditions on long haul flights, hence “economy class syndrome”. In other patients, especially where internal organs such as the brain are affected, the condition may be more difficult to diagnose.

In others, the antibody (the sticky blood ‘tendency’) may be present without any medical problems having been seen. In other words, there is a wide variety of clinical pictures seen with the syndrome.

Vein thrombosis
  • e.g. DVT, pulmonary embolism ‘Economy Class Syndrome’ or thrombosis on the pill
  • Artery thrombosis
  • e.g. limb pain, organ thrombosis
  • Pregnancy
  • recurrent miscarriage, including early and late pregnancy loss
  • Infertility
  • Intra uterine growth retardation
  • Brain

  • headache and migraine
  • stroke and TIA
  • memory loss
  • balance disorder (and sometimes hearing impairment)
  • seizures
  • ‘atypical’ multiple sclerosis
  • speech disturbance
  • movement disorder, including Chorea (St Vitus dance)
  • absences
  • severe dementia (rare: untreated cases)
  • Heart and lungs

     

  • heart attacks, murmurs
  • lung thrombosis (pulmonary embolism)
  • shortness of breath
  • pulmonary hypertension (raised pressure)
  • valve failure (rare)
  • angina
  • Eye

  • sudden visual loss (clots around the eye)
  • loss of part of field of vision
  • Dry eyes (Sjogrens’s Syndrome)
  • Skin

  • 'blotchy' circulation (‘livedo’)
  • skin ulcers and nodules
  • cold circulation
  • Kidney
  • thrombosis in artery or vein
  • raised blood pressure
  • Liver
  • liver thrombosis
  • Blood
  • low platelets counts
  • General
  • fatigue
  • aches and pains
  • 'Catastrophic' APS (widespread sudden thrombosis)

  • For further information, please refer to the book: A Patients Guide, written by Dr Graham Hughes which can be purchased from our publications page.