Published research articles

Below is a selected list of peer-reviewed research articles produced by the Lupus Unit at St Thomas' Hospital - where the Hughes Syndrome clinic is held, published between 1989 - 2008.

Edwards CJ, Hughes GR
Hughes syndrome (the antiphospholipid syndrome): 25 years old.
Mod Rheumatol. 2008;18(2):119-24. Epub 2008 Mar 4

Sangle SR, D'Cruz DP
Syndrome X (angina pectoris with normal coronary arteries) and myocardial infarction in patients with anti-phospholipid (Hughes) syndrome.
Lupus. 2008;17(2):83-5

Sangle S, Christodoulou C, Paul S, Hughes GR, D'Cruz DP
The point prevalence of an abnormal ankle-brachial index in antiphospholipid antibody negative patients with livedo reticularis: a controlled study.
Ann Rheum Dis. 2008 Feb;67(2):276-7.

Hughes GR
Hughes Syndrome (the antiphospholipid syndrome): ten clinical lessons.
Autoimmun Rev. 2008 Jan;7(3):262-6. Epub 2007 Dec 7.

Ruiz-Irastorza G, Khamashta MA
The treatment of antiphospholipid syndrome: a harmonic contrast.
Best Pract Res Clin Rheumatol. 2007 Dec;21(6):1079-92.

Hamid C, Norgate K, D'Cruz DP, Khamashta MA, Arno M, Pearson JD, Frampton G, Murphy JJ.
Anti-{beta}2GPI-antibody-induced endothelial cell gene expression profiling reveals induction of novel pro-inflammatory genes potentially involved in primary antiphospholipid syndrome.
Ann Rheum Dis. 2007 Aug;66(8):1000-1007. Epub 2007 Jan 12

Garcia DA, Khamashta MA, Crowther MA.
How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review
Blood. 2007 Jul 20

Uthman I, Khamashta M
The abdominal manifestations of the antiphospholipid syndrome
Rheumatology (Oxford). 2007 Jul 17

Ruiz-Irastorza G, Khamashta MA.
Antiphospholipid syndrome in pregnancy
Rheum Dis Clin North Am. 2007 May;33(2):287-97, vi.

Christodoulou C, Sangle S, D'Cruz DP
Vasculopathy and arterial stenotic lesions in the antiphospholipid syndrome
Rheumatology (Oxford). 2007 Apr 2

Davies JO, Hunt BJ
Myocardial infarction in young patients without coronary atherosclerosis: assume primary antiphospholipid syndrome until proved otherwise
Int J Clin Pract. 2007 Mar;61(3):379-384

Wiles NM, Hunt BJ, Callanan V, Chevretton EB
Sudden sensorineural hearing loss and antiphospholipid syndrome.
Haematologica. 2006 Dec;91(12 Suppl):ECR46

Kamat AV, D'Cruz DP, Hunt BJ.
Managing antiphospholipid antibodies and antiphospholipid syndrome in children
Haematologica. 2006 Dec;91(12):1674-80

Davies RJ, Sangle SR, Khamashta MA, D'Cruz DP
Antiphospholipid (Hughes) syndrome and atheroma
Lupus 2006 Supplement; 15(1), S55-S58

Rosenthal E, Sangle SR, Taylor P, Khamashta MA, Hughes GR, D'Cruz DP
Treatment of mesenteric angina with prolonged anticoagulation in a patient with antiphospholipid (Hughes) syndrome and coeliac artery stenosis
Ann Rheum Dis. 2006 Oct;65(10):1398-9

Bertolaccini ML, Hughes GR
Antiphospholipid antibody testing: which are most useful for diagnosis?
Rheum Dis Clin North Am. 2006 Aug;32(3):455-63

Sanna G, D'Cruz D, Cuadrado MJ
Cerebral manifestations in the antiphospholipid (Hughes) syndrome
Rheum Dis Clin North Am. 2006 Aug;32(3):465-90

Bertolaccini ML, Khamashta MA
Laboratory diagnosis and management challenges in the antiphospholipid syndrome
Lupus. 2006;15(3):172-8

Rosenthal E, Sangle SR, Khamashta MA, D'Cruz D, Hughes GR
Orthopedic manifestations of the antiphospholipid syndrome
Rev Med Interne. 2006 Jun 30

Sangle SR, Jan W, Lau IS, Bennett AN, Hughes GR, D'Cruz DP
Coeliac artery stenosis and antiphospholipid (Hughes) syndrome/antiphospholipid anti-bodies
Clin Exp Rheumatol. 2006 May-Jun;24(3):349

Christodoulou C, Zain M, Bertolaccini ML, Sangle S, Khamashta MA, Hughes GR, D'Cruz DP
Prevalence of an abnormal ankle-brachial index in patients with antiphospholipid syndrome with pregnancy loss but without thrombosis: a controlled study
Ann Rheum Dis. 2006 May;65(5):683-4

Rees JD, Lanca S, Marques PV, Gomez-Puerta JA, Moco R, Oliveri C, Khamashta MA, Hughes GR, D'Cruz DP
Prevalence of the antiphospholipid syndrome in primary systemic vasculitis
Ann Rheum Dis. 2006 Jan;65(1):109-11

Gomez-Puerta, Jose A. MD; Martin, Helena MD; Amigo, Mary-Carmen MD; Aguirre, Maria A. MD; Camps, Maria T. MD; Cuadrado, Maria J. MD, PhD; Hughes, Graham R. V. MD, FRCP; Khamashta, Munther A. MD, FRCP, PhD
Long term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus?
Medicine, July 2005; 84 (4)

Sanna G, Bertolaccini ML, Hughes GR
Hughes syndrome, the antiphospholipid syndrome: a new chapter in neurology
Ann N Y Acad Sci. 2005 Jun;1051:465-86

Ferreira DP, D'Cruz DP, Hughes GRV
Multiple sclerosis, neuropsychiatric lupus and antiphospholipid (Hughes) Syndrome: where do we stand?
Rheumatology, January 2005

Sangle SR, D'Cruz DP, Abbs IC, Khamashta MA, Hughes GRV
Renal artery stenosis in hypertensive patients with antiphospholipid (Hughes) syndrome: outcome following anticoagulation
Rheumatology 2005; 44: 372-377

Harris EN, Khamashta M
Anticardiolipin Test and the Antiphospholipid (Hughes) Syndrome: 20 Years and counting
JRheum 2004; 31: 2099-2101

Khamashta MA, Bertolaccini, ML, Hughes GRV
Antiphospholipid (Hughes) Syndrome
Autoimmunity June 2004; 37(4): 309-312

Sangle, SR, D'Cruz, DP, Khamashta MA, Hughes GRV
Antiphospholipid antibodies, systemic lupus erythematosus and non-traumatic metatarsal fractures
Ann Rheum Dis 2004; 63: 1241-1243

Hughes GRV
Migraine, memory loss and "multiple sclerosis". Neurological features of the antiphospholipid (Hughes) syndrome
PMJ 2003; 79: 81-83

Hughes GRV, Khamashta MA
Seronegative antiphospholipid syndrome
Ann Rheum Dis 2003, 62 1127

Cuadrado MJ
Treatment and monitoring of patients with antiphospholipid antibodies and thrombotic history (Hughes syndrome)
Curr Rheumatol Rep. 2002 Oct, 4(5) 392-8

Hughes GRV
The history of Hughes syndrome
Elias Journal; September 2002

Cuadrado MJ, Khamashta MA, Hughes GRV
Sticky blood and headache
Lupus 2001; 10: 392-393

Cuadrado MJ, Khamashta MA, D'Cruz D, Hughes GRV
Migraine in Hughes Syndrome - heparin as a therapeutic trial?
Q J Med 2001; 94: 114-115

Bertolaccini ML, Atsumi T, Escudero Contreras A, Khamashta MA, Hughes GRV
Value of IgA antiphospholipid testing for the diagnosis of antiphospholipid (Hughes) syndrome in systematic lupus erythematosus.
J Rheumatology 2001 Dec; 28(12) :2637-43.

Hughes GRV, Cuadrado MJ, Khamashta MA, Sanna G
Headache and memory loss: rapid response to heparin in the antiphospholipid syndrome
Lupus 2001; 10: 778

Cuadrado MJ and Hughes GRV
Hughes (antiphospholipid) syndrome: clinical features
Rheumatic Disease Clinics, August 2001; 27(3): 507-524

Godfrey T, Khamashta MA, Hughes GRV, Abbs I
Antiphospholipid syndrome and renal artery stenosis.
Q J Med 2000; 93: 172-179

Cuadrado MJ, Khamashta MA, Ballesteros A, Godfrey T, Simon MJ, Hughes GRV
Can Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of literature
Medicine (Baltimore) 2000; 79: 57-68

Romero FI, Amengual O, Atsumi T, Khamashta MA, Tinahones FJ, Hughes GRV
Arterial disease in lupus and secondary antiphospholipid syndrome: association with anti-B2-Glycoprotein I antibodies but not with antibodies against low-density lipoprotein
Br J Rheumatol 1998; 37: 883-888

Bertolaccini ML, Astumi T, Khamashta MA, Amengual O, Hughes GRV
Autoantibodies to human prothrombin and clinical manifestations in 207 patients with systemic lupus erythematosus
J Rheumatol 1998; 25: 1104-1108

Bertolaccini ML, Roch, B Amengual O, Astumi T, Khamashta MA, Hughes GRV
Multiple antiphospholipid tests do not increase the diagnostic yield in Antiphospholipid Syndrome
Br J Rheumatol 1998; 37: 1229-1232

Hughes GRV
Hughes Syndrome: the antiphospholipid syndrome. A historical view
Lupus 1998 7 Supplement S1-S4

Cuadrado MJ, Mujic F, Munoz E, Khamashta MA, Hughes GRV
Thrombocytopenia in the antiphospholipid syndrome
Ann Rheum Dis 1997; 56: 194-196

Hunt BJ, Doughty HA, Majumdar G, Copplestone A, Kerslake S, Buchanan N, Hughes GRV, Khamashta MA
Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies
Thromb Haemost 1997; 77: 39-43

Lima F, Khamashta MA, Buchanan NMM, Kerslake S, Hunt B, Hughes GRV
A study of sixty pregnancies in patients with the Antiphospholipid Syndrome
Clin Exp Rheumatol 1996; 14: 131-136

Toubi E, Khamashta MA, Panarra A, Hughes GRV
Association of Antiphospholipid Antibodies with central nervous system disease in systemic lupus erythematosus
Am J Med 1995: 99:397-401

Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR
The management of thrombosis in the antiphospholipid antibody syndrome
N Engl J Med 1995; 332: 993-997

Vianna JL, Khamashta MA, Ordi-Ros J, Font J, Cervera R, Lopez-Soto A, Tolosa C, Franz J, Selva A, Ingelmo M, Vilardell M, Hughes GRV
Comparison of the primary and secondary antiphospholipid syndrome . A European multi-centre study of 114 patients
Am J Med 1994; 96:3-9

Herranz MT, Rivier G, Khamashta MA, Blaser KU, Hughes GRV
Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus
Arthritis Rheum 1994; 37: 568-571

Montalban J, Codina A, Ordi J, Vildarell M, Khamashta MA, Hughes GRV
Antiphospholipid antibodies in cerebral ischemia
Stroke 1991; 22: 750-753

Khamashta MA, Cervera R, Asherton RA, Font J, Gil A, Coltart DJ, Vazquez JJ, Pare C, Ingelmo M, Oliver J, Hughes GRV
Association of Antiphospholipid antibodies with heart valve disease in systemic lupus erythematosus. A European multicentre prospective study of 132 patients
Lancet 1990; 335: 1541-1544

Asherton RA, Khamashta MA, Ordi-Ros J, Derksen RHWM, Machin SJ, Barquinero J, Out HJ, Harris EN, Vilardell-Tarres M, Hughes GRV
The "Primary" Antiphospholipid Syndrome: Major clinical and serological features.
Medicine (Baltimore) 1989; 86: 366-374

Asherton RA, Khamashta MA, Gil A, Vazquez JJ, Chan O, Baguley E, Hughes GRV
Cerebro-vascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus like disease and the primary antiphospholipid syndrome.
Am J Med 1989; 86: 391-399