Hughes Syndrome Foundation
E-News Updates »   Online Communities »   Join Us »

What are the symptoms of Hughes/antiphospholipid syndrome

Hughes/antiphospholipid syndrome can cause both low-grade symptoms and potentially fatal conditions as a result of blood clots.

In pregnancy, Hughes/antiphospholipid syndrome is the most common, potentially treatable cause of recurrent miscarriage, and is also associated with other complications such as pre-eclampsia, premature birth and stillbirth.

Some people are affected by symptoms more than others, while others may have the antiphospholipid antibodies (aPL) but do not develop any blood clots and/or have pregnancy complications. As of yet, we simply don’t know the reason why these anomalies exist because so much research still needs to be carried out.

The typical low-grade symptoms of Hughes/antiphospholipid syndrome are:

The common acute conditions caused by Hughes/antiphospholipid syndrome are:

As Hughes/antiphospholipid syndrome is a blood disorder and blood flows throughout the entire body, nearly any organ can be affected. Consequently, the brain, eyes, ears, lungs, heart, kidneys, liver, bowel, skin, nails, bones and joints can potentially all be affected to varying degrees.

The brain is particularly susceptible in Hughes/antiphospholipid syndrome patients, as the ‘sticky blood’ can impair circulation and limit oxygen which can result in a variety of low-grade neurological symptoms.

Remember - it is NOT necessary to have all the symptoms to be diagnosed with Hughes/antiphospholipid syndrome.

The brain

The brain is particularly susceptible in Hughes/antiphospholipid syndrome patients as the ‘sticky blood’ results in impaired circulation and less oxygen which causes diminished mental alertness


Hughes/antiphospholipid syndrome is usually associated with recurrent miscarriage, but it can also cause other pregnancy complications. View our overview of pregnancy problems for patients with HS

© 2016 The Hughes Syndrome Foundation. Registered Charity Number 1138116. A company limited by guarantee registered in England 7268671.